Spreading Hedyotis Herb — Safety & Interactions

Contraindications

• Spleen-Stomach Deficiency Cold — cold-bitter nature strongly contraindicated with loose stools, poor appetite, and cold abdomen; prolonged use impairs digestive Yang
• Qi and Blood deficiency without Heat — inappropriate for deficiency patterns lacking toxic Heat presentation

Cautions

• Standard dose: 15–60 g dried herb in decoction; doses up to 120 g/day used in clinical oncology settings under supervision
• Generally considered safe at therapeutic doses with no major systemic toxicity documented in clinical use or animal studies
• Anticoagulants and antiplatelets: flavonoids and phenolic acids have mild antiplatelet activity — monitor bleeding parameters with concurrent use at very high doses
• Immunosuppressants: polysaccharide fraction enhances immune function; theoretical antagonism with immunosuppressant drugs (tacrolimus, cyclosporine) — avoid concurrent use without transplant physician review
• Pregnancy: cold-natured, large-dose use traditionally avoided in pregnancy; no formal teratogenicity data but caution advised

Drug Interactions