Use with caution. Review interactions and contraindications below.
TCM Properties
- Taste
- salty
- Temperature
- slightly cold
- Channels
- Liver, Stomach
Traditional Use
Primary Actions
- Activates Blood and dissolves Blood Stasis — amenorrhea, dysmenorrhea, Blood Stasis masses, and post-partum lochia retention; one of the strongest Blood-activating drugs in classical TCM pharmacopoeia; salty-cold nature penetrates deeply into Blood level
- Reduces swelling and expels pus — unruptured abscesses, carbuncles, mastitis, and swollen lymph nodes; the principal classical use for promoting abscess suppuration and drainage; promotes ripening of unruptured sores
- Unblocks lactation vessels — insufficient lactation (agalactia) from Qi and Blood obstruction; classical first-line herb for post-partum lactation promotion, often combined with Wang Bu Liu Xing (Vaccaria seeds)
- Disperses nodules and scrofula — thyroid nodules, lymph node enlargement, and abdominal Blood Stasis masses; the 'channel-opening, nodule-dispersing' action of the scaled drug
Secondary Actions
- Opens channels and dispels Wind-Damp — severe Bi syndrome with numbness, pain, and joint obstruction; Chuan Shan Jia penetrates channels and disperses obstruction deep in connective tissue
- Historically used for Zheng Jia (abdominal masses) — teratoma-type solid masses from Blood Stasis and Phlegm accumulation
Classic Formulas
- Xian Fang Huo Ming Yin (仙方活命饮) — classical abscess and carbuncle formula; Chuan Shan Jia as a key channel-opening, swelling-dispersing ingredient; combined with Bai Zhi, Fang Feng, Jin Yin Hua, Ru Xiang, Mo Yao, and Gan Cao; one of the primary formulas for unruptured hot abscesses in classical surgery
- Tong Ru Dan (通乳丹) — lactation-promoting formula; Chuan Shan Jia combined with Wang Bu Liu Xing (Vaccaria), Bei Mu, and Mu Tong for post-partum insufficient lactation from Blood and Qi obstruction
- Tou Nong San (透脓散) — promotes suppuration in chronic recalcitrant abscesses; Chuan Shan Jia with Huang Qi, Dang Gui, Chuan Xiong, and Zao Jiao Ci
Classical References
- Ben Cao Gang Mu (Li Shizhen): 'Chuan Shan Jia (穿山甲, the mountain-traversing armadillo/pangolin) — salty, slightly cold; enters Liver and Stomach; activates Blood, reduces swellings, expels pus, opens lactation channels; the scales are the medicinal part — roasted in sand and ground to powder; treated with vinegar to enhance Blood-activating penetration; this animal burrows through mountains and swims through rivers — hence its power to penetrate and open obstructions in channels'
- CONSERVATION AND LEGAL STATUS — CRITICAL: Chuan Shan Jia (穿山甲) is derived from the Chinese pangolin (Manis pentadactyla) and related species — the world's most trafficked mammals. All eight pangolin species are listed on CITES Appendix I (international commercial trade banned since 1975); Chinese pangolin (M. pentadactyla) is classified as Critically Endangered on the IUCN Red List. Chuan Shan Jia was removed from the official Chinese Pharmacopoeia (ChP) in the 2020 edition due to the species' critically endangered status — it is now a protected species under Chinese national law. Any clinical prescription, dispensing, or sale of Chuan Shan Jia is illegal in China and under international wildlife law. Clinically validated substitutes: Zao Jiao Ci (Gleditsia spines) for abscess/swelling; Wang Bu Liu Xing (Vaccaria seeds) alone for lactation; San Leng/E Zhu for Blood Stasis masses.
Modern Research
Active Compounds
- Cyclic dipeptides (diketopiperazines) — dominant bioactive fraction in pangolin scales; anti-inflammatory in vitro
- Stearic acid and palmitic acid (fatty acids) — majority lipid fraction
- Zinc, manganese, and trace minerals — relatively high concentration
- d-Serine and amino acid derivatives — minor fraction
- Keratin (structural protein matrix) — majority composition of scales
Studied Effects
- Anti-inflammatory: cyclic dipeptide and fatty acid fractions from Squama Manitis show COX-2 inhibition and TNF-α reduction in macrophage models; modest anti-inflammatory activity consistent with abscess-resolving and Bi-syndrome-treating classical indications
- Lactation promotion: water extracts of Squama Manitis increase serum prolactin levels in animal models and improve milk production in rodent lactation studies; mechanism may involve prolactin-releasing factor stimulation; validates the classical Tong Ru (unblocking lactation) application, though clinical human evidence is limited
- NOTE: The ethical and legal unacceptability of pangolin scale sourcing means that modern pharmacological research on this drug is appropriately limited and declining; conservation and substitute research is now the priority
Safety & Interactions
Contraindications
- Pregnancy — absolutely contraindicated; strong Blood-activating action causes uterine contractions and significant risk of miscarriage; one of the strongest classical pregnancy contraindications in TCM
- Open abscesses with pus already draining — the 'promoting suppuration' action is only appropriate for unruptured abscesses; inappropriate if rupture has already occurred
- Qi and Blood Deficiency without Stasis — powerful Blood-moving drug requires adequate Qi to drive; exhausts Qi in severely deficient patients
- LEGAL: possession and use of genuine Chuan Shan Jia is illegal in China (2020 ChP removal) and internationally (CITES Appendix I); practitioners must use validated substitutes
Cautions
- Historical dose: 3–10 g roasted scales in decoction; 1–1.5 g powder (chong fu); the drug was always processed (roasted in sand or vinegar-treated) before internal use
- ETHICAL AND LEGAL ADVISORY: Chuan Shan Jia should not be used in clinical practice; any product claiming to contain genuine pangolin scales is either illegal or fraudulent; validated TCM substitutes exist for all classical indications
- Adulteration: given the species ban, commercially available 'Chuan Shan Jia' is frequently adulterated with pig skin, fish scales, or synthetic polymer scales; practitioners should be aware that authentic pangolin-derived products cannot be legally sourced
Drug Interactions
- Anticoagulants (warfarin, heparin, aspirin) — additive Blood-activating and anticoagulant effects; increases bleeding risk
- NSAIDs — additive anti-inflammatory and platelet-inhibitory effects