Use with caution. Review interactions and contraindications below.
TCM Properties
- Taste
- bitter, acrid
- Temperature
- cold
- Channels
- Liver, Spleen, Kidney
Traditional Use
Primary Actions
- Clears Heat and promotes urination — used for Damp-Heat jaundice, painful urinary disorders, and summer-heat dysentery
- Resolves toxicity and reduces swelling — applied internally or topically for abscesses, sores, shingles, and inflamed skin lesions
- Promotes tissue regeneration and wound healing — valued for traumatic injury, chronic sores, burns, and delayed healing
- Cools Blood and stops bleeding while also invigorating Blood — used for blood in the urine, epistaxis, bruising, and traumatic swelling
Secondary Actions
- Supports the Liver and Gallbladder in Damp-Heat patterns with jaundice or hepatitis
- Fresh herb juice or poultice is a classic folk application for red eyes, sore throat, and hot swellings
Classical References
- Shen Nong Ben Cao Jing (Divine Husbandman's Classic of Materia Medica) — records Ji Xue Cao as bitter and cold, indicated for great Heat, malignant sores, abscesses, spreading sores, red skin lesions, and fever.
- Xin Xiu Ben Cao (Tang dynasty) — describes the coin-shaped leaves and recommends the pounded fresh herb applied topically for hot swellings and erysipelas.
- Ben Cao Gang Mu (Compendium of Materia Medica, Li Shizhen, 1578) — notes that the expressed juice can be used for sudden red eyes and other acute Heat conditions.
Modern Research
Active Compounds
- Asiaticoside
- Madecassoside
- Asiatic acid
- Madecassic acid
- Flavonoids and polyphenols
Studied Effects
- Wound-healing and collagen support — asiaticoside increased collagen content, tensile strength, and epithelization in normal and delayed wound-healing models (PMID 10350364)
- Chronic venous insufficiency support — systematic review found improvement in microcirculatory parameters, edema, and related symptoms in controlled trials (PMID 23533507)
- Dermatologic scar and burn support — review literature highlights triterpenes for small wounds, hypertrophic scars, and burns (PMID 24399761)
PubMed References
Safety & Interactions
Contraindications
- Spleen and Stomach deficiency-cold with loose stools or poor appetite
- Cold-pattern dysmenorrhea or menstruation with marked Cold signs
Cautions
- High doses or prolonged use may cause digestive upset or contribute to liver irritation in susceptible patients
- Use with caution in patients with existing liver disease or when combining with other potentially hepatotoxic supplements
Drug Interactions
-
CYP450 substrate drugs
— In vitro gotu kola inhibits CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 and may alter intracellular concentrations of substrate drugs (Moderate)
Source: Memorial Sloan Kettering Integrative Medicine — Gotu Kola