Bark of Amur Corktree

Chinese
黄柏
Pinyin
Huang Bai
Latin
Cortex Phellodendri

TCM Properties

Taste
bitter
Temperature
cold
Channels
Kidney, Bladder, Large Intestine

Traditional Use

Primary Actions

  • Clears damp-heat from the lower burner - used for painful dark urination, leukorrhea, dysenteric diarrhea, jaundice, swollen painful lower limbs, and genital damp-heat where bitterness and coldness are needed to dry and drain downward.
  • Drains deficiency fire from Kidney Yin deficiency - an important herb for tidal fever, bone steaming, night sweats, seminal emission, and lower-burner heat signs in formulas such as Zhi Bai Di Huang Wan.
  • Resolves fire toxin and damp skin lesions - applied internally or externally for eczema, sores, hot toxic swellings, and damp-heat eruptions with redness, itching, oozing, or foul discharge.
  • Directs heat downward from the intestines and bladder - especially useful when damp-heat causes tenesmus, foul diarrhea, or lower-abdominal burning that requires a strong descending bitter-cold approach.

Secondary Actions

  • Often paired with Cang Zhu as the classic Huang Bai-Cang Zhu combination when damp-heat has sunk into the legs, knees, or lower burner.
  • Its strong drying nature means it is often balanced with Yin-nourishing or Spleen-supporting herbs when deficiency and excess coexist.

Classic Formulas

  • Er Miao San (二妙散) - the classic two-herb combination of Huang Bai and Cang Zhu for damp-heat pouring downward with red swollen legs, genital itching, and lower-burner inflammation.
  • Bai Tou Weng Tang (白头翁汤) - from Shang Han Lun, where Huang Bai assists in treating toxic-heat dysentery with tenesmus, blood, and severe intestinal inflammation.
  • Zhi Bai Di Huang Wan (知柏地黄丸) - the well-known extension of Liu Wei Di Huang Wan that adds Huang Bai and Zhi Mu to drain deficiency fire from Kidney-Liver Yin deficiency.

Classical References

  • IMPORT NOTE: The XLSX source imported the pinyin as 'Huang Bi', but the standard TCM name for Cortex Phellodendri is Huang Bai (黄柏). This record preserves the slug while correcting the herbal identity.
  • IDENTITY NOTE: This record is therapeutically identical to the later English-variant stub phellodendron-bark.json. The duplicate reflects an import naming split rather than a separate drug.
  • Shen Nong Ben Cao Jing and later materia medica traditions established Huang Bai as a bitter-cold lower-burner herb for damp-heat, dysentery, jaundice, and deficiency fire patterns.

Modern Research

Active Compounds

  • Berberine (protoberberine alkaloid) - the best-known antimicrobial and anti-inflammatory constituent in Huang Bai bark
  • Palmatine (isoquinoline alkaloid) - contributes anti-inflammatory and metabolic activity
  • Jatrorrhizine (protoberberine alkaloid) - studied for antimicrobial and gastrointestinal activity
  • Phellodendrine (alkaloid) - associated with anti-inflammatory and immunomodulatory effects
  • Obacunone and obaculactone (limonoids) - highlighted in review literature for dermatologic and anti-atopic potential

Studied Effects

  • Comprehensive review literature describes broad anti-inflammatory, antibacterial, antiviral, antitumor, antigout, neuroprotective, and anti-atopic activities across Phellodendri Cortex compounds and extracts (PMID 31057654)
  • Cartilage-protective effects - Phellodendron amurense extract reduced matrix degradation, inflammatory mediators, and MAPK signaling in human osteoarthritic cartilage and chondrocytes (PMID 21182922)
  • Diabetic nephropathy modulation - polysaccharide fractions altered PI3K, GSK-3beta, Nrf2, and TGF-beta/Smad signaling while shifting gut microbiota in experimental diabetic nephropathy (PMID 41518482)
  • The review literature also highlights obacunone-class compounds as candidate drivers of anti-atopic dermatitis effects, aligning with Huang Bai's traditional role in damp-heat skin disease (PMID 31057654)

PubMed References

Safety & Interactions

Contraindications

  • Spleen and Stomach deficiency-cold, especially with chronic diarrhea
  • Absence of damp-heat, deficiency fire, or toxic heat signs

Cautions

  • Its bitter-cold drying action can injure the middle burner and worsen poor appetite, abdominal cold, or chronic loose stools if used for too long
  • Because berberine-containing bark preparations may require extra caution in peripartum, neonatal, or hemolytic-risk settings, use should remain practitioner-guided rather than casual self-medication
  • MSK page not found - drug interaction data not available from Memorial Sloan Kettering integrative medicine database

Conditions