Use with caution. Review interactions and contraindications below.
TCM Properties
- Taste
- bitter, acrid
- Temperature
- warm
- Channels
- Lung, Large Intestine, Spleen, Stomach
Traditional Use
Primary Actions
- Moves Qi and resolves focal distention - a key herb for fullness, bloating, abdominal pain, epigastric oppression, and food stagnation when stagnant Qi knots in the middle burner.
- Dries Dampness and harmonizes the Spleen-Stomach - used when damp obstruction causes poor appetite, nausea, greasy coating, sluggish digestion, loose stool, and heavy obstructed sensation.
- Descends rebellious Qi and transforms phlegm - classically used for wheezing, cough, chest congestion, plum-pit Qi, and phlegm-damp obstruction of the throat and chest.
- Opens constrained downward movement in the intestines - especially helpful in constipation where Qi stagnation and fullness predominate more than severe dryness or blood deficiency.
Secondary Actions
- Frequently included in formulas to prevent rich tonics or greasy damp-resolving herbs from causing secondary stagnation.
- Its warm aromatic bitterness makes it especially useful when emotional constraint, phlegm, and digestive blockage overlap, as in globus sensation and stress-related nausea.
Classic Formulas
- Ban Xia Hou Pu Tang (半夏厚朴汤) - from Jin Gui Yao Lue, combining Hou Pu with Ban Xia, Fu Ling, Sheng Jiang, and Zi Su Ye for plum-pit Qi, throat obstruction, nausea, and emotional constraint with phlegm.
- Ping Wei San (平胃散) - the classic dampness-transforming formula in which Hou Pu helps move Qi, dry damp, and relieve epigastric and abdominal fullness.
- Hou Pu San Wu Tang (厚朴三物汤) - from Jin Gui Yao Lue, using Hou Pu with Zhi Shi and Da Huang for abdominal fullness, pain, and constipation driven by severe Qi stagnation.
- Ma Zi Ren Wan (麻子仁丸) - includes Hou Pu to move constrained Qi and assist bowel opening in dry constipation with abdominal distention.
Classical References
- Classical materia medica consistently describe Hou Pu as bitter, acrid, warm, and aromatic, entering the Spleen and Stomach to move Qi, dry dampness, and direct stagnation downward.
- Zhang Zhongjing's formulas use Hou Pu repeatedly when fullness, phlegm, and impaired descent are central, especially in Ban Xia Hou Pu Tang and Hou Pu San Wu Tang.
- Sacred Lotus preserves the standard caution that Hou Pu should be used carefully in pregnancy and in clear Qi-deficiency states because its descending, moving action is relatively strong.
Modern Research
Active Compounds
- Magnolol (neolignan) - one of the two signature bioactive compounds in Hou Pu bark with anti-inflammatory, antiplatelet, and neuroactive effects
- Honokiol (neolignan) - major anxiolytic, anti-inflammatory, and antitumor research constituent
- Obovatol (biphenolic neolignan) - contributes anti-inflammatory and neuroprotective research interest
- 4-O-methylhonokiol (neolignan derivative) - studied for neuroprotective and anti-inflammatory potential
- Essential oil sesquiterpenes and related aromatic constituents - support the bark's volatile digestive and antimicrobial profile
Studied Effects
- Mechanistic review literature details anti-inflammatory, antioxidant, antimicrobial, and apoptosis-targeting anticancer actions of magnolol and honokiol from Magnolia officinalis bark (PMID 22466367)
- Pain and inflammatory mediator modulation - honokiol and magnolol reduced glutamatergic and inflammatory pain responses in animal models, supporting the herb's traditional fullness-and-pain indications (PMID 19832997)
- More recent review work summarizes broad structure-activity and pharmacologic findings for magnolol and honokiol derivatives, reinforcing continued interest in neuroprotective, anti-inflammatory, and antitumor applications (PMID 38714288)
- MSK's clinical summary notes Magnolia officinalis is also used to regulate gastrointestinal motility, which fits the classical profile of descending and unblocking middle-burner Qi.
PubMed References
Safety & Interactions
Contraindications
- Qi deficiency or dryness without true stagnation, dampness, or phlegm obstruction
- Yin deficiency dryness with depleted fluids and no damp blockage
Cautions
- Its warm, aromatic, drying nature can aggravate thirst, dry constipation, or depletion if used too aggressively in already dry patients
- Use with caution during pregnancy because its strong Qi-moving and descending action may disturb fetal stability in susceptible patients
Drug Interactions
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Diabetes medications
— Magnolia bark extract may enhance glucose-lowering effects and increase the risk of hypoglycemia (Moderate)
Source: Memorial Sloan Kettering Integrative Medicine - Magnolia officinalis
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Sleep or anxiety medications
— Magnolia bark extract may increase sedative or anxiolytic effects (Moderate)
Source: Memorial Sloan Kettering Integrative Medicine - Magnolia officinalis
-
Blood thinners
— Magnolia bark extract may increase bleeding risk (Moderate)
Source: Memorial Sloan Kettering Integrative Medicine - Magnolia officinalis
-
CYP450 substrate drugs
— Magnolia bark extract may alter drug metabolism and change the effects of medications handled by CYP pathways (Moderate)
Source: Memorial Sloan Kettering Integrative Medicine - Magnolia officinalis
-
P-gp substrate drugs
— Magnolia bark extract may alter transporter-mediated drug disposition and modify medication exposure (Moderate)
Source: Memorial Sloan Kettering Integrative Medicine - Magnolia officinalis
-
UGT substrate drugs
— Magnolia bark extract may alter glucuronidation-dependent drug clearance (Moderate)
Source: Memorial Sloan Kettering Integrative Medicine - Magnolia officinalis