Bark of Officinal Magnolia

Chinese
厚朴
Pinyin
Hou Pu
Latin
Cortex Magnoliae Officinalis

TCM Properties

Taste
bitter, acrid
Temperature
warm
Channels
Lung, Large Intestine, Spleen, Stomach

Traditional Use

Primary Actions

  • Moves Qi and resolves focal distention - a key herb for fullness, bloating, abdominal pain, epigastric oppression, and food stagnation when stagnant Qi knots in the middle burner.
  • Dries Dampness and harmonizes the Spleen-Stomach - used when damp obstruction causes poor appetite, nausea, greasy coating, sluggish digestion, loose stool, and heavy obstructed sensation.
  • Descends rebellious Qi and transforms phlegm - classically used for wheezing, cough, chest congestion, plum-pit Qi, and phlegm-damp obstruction of the throat and chest.
  • Opens constrained downward movement in the intestines - especially helpful in constipation where Qi stagnation and fullness predominate more than severe dryness or blood deficiency.

Secondary Actions

  • Frequently included in formulas to prevent rich tonics or greasy damp-resolving herbs from causing secondary stagnation.
  • Its warm aromatic bitterness makes it especially useful when emotional constraint, phlegm, and digestive blockage overlap, as in globus sensation and stress-related nausea.

Classic Formulas

  • Ban Xia Hou Pu Tang (半夏厚朴汤) - from Jin Gui Yao Lue, combining Hou Pu with Ban Xia, Fu Ling, Sheng Jiang, and Zi Su Ye for plum-pit Qi, throat obstruction, nausea, and emotional constraint with phlegm.
  • Ping Wei San (平胃散) - the classic dampness-transforming formula in which Hou Pu helps move Qi, dry damp, and relieve epigastric and abdominal fullness.
  • Hou Pu San Wu Tang (厚朴三物汤) - from Jin Gui Yao Lue, using Hou Pu with Zhi Shi and Da Huang for abdominal fullness, pain, and constipation driven by severe Qi stagnation.
  • Ma Zi Ren Wan (麻子仁丸) - includes Hou Pu to move constrained Qi and assist bowel opening in dry constipation with abdominal distention.

Classical References

  • Classical materia medica consistently describe Hou Pu as bitter, acrid, warm, and aromatic, entering the Spleen and Stomach to move Qi, dry dampness, and direct stagnation downward.
  • Zhang Zhongjing's formulas use Hou Pu repeatedly when fullness, phlegm, and impaired descent are central, especially in Ban Xia Hou Pu Tang and Hou Pu San Wu Tang.
  • Sacred Lotus preserves the standard caution that Hou Pu should be used carefully in pregnancy and in clear Qi-deficiency states because its descending, moving action is relatively strong.

Modern Research

Active Compounds

  • Magnolol (neolignan) - one of the two signature bioactive compounds in Hou Pu bark with anti-inflammatory, antiplatelet, and neuroactive effects
  • Honokiol (neolignan) - major anxiolytic, anti-inflammatory, and antitumor research constituent
  • Obovatol (biphenolic neolignan) - contributes anti-inflammatory and neuroprotective research interest
  • 4-O-methylhonokiol (neolignan derivative) - studied for neuroprotective and anti-inflammatory potential
  • Essential oil sesquiterpenes and related aromatic constituents - support the bark's volatile digestive and antimicrobial profile

Studied Effects

  • Mechanistic review literature details anti-inflammatory, antioxidant, antimicrobial, and apoptosis-targeting anticancer actions of magnolol and honokiol from Magnolia officinalis bark (PMID 22466367)
  • Pain and inflammatory mediator modulation - honokiol and magnolol reduced glutamatergic and inflammatory pain responses in animal models, supporting the herb's traditional fullness-and-pain indications (PMID 19832997)
  • More recent review work summarizes broad structure-activity and pharmacologic findings for magnolol and honokiol derivatives, reinforcing continued interest in neuroprotective, anti-inflammatory, and antitumor applications (PMID 38714288)
  • MSK's clinical summary notes Magnolia officinalis is also used to regulate gastrointestinal motility, which fits the classical profile of descending and unblocking middle-burner Qi.

PubMed References

Safety & Interactions

Contraindications

  • Qi deficiency or dryness without true stagnation, dampness, or phlegm obstruction
  • Yin deficiency dryness with depleted fluids and no damp blockage

Cautions

  • Its warm, aromatic, drying nature can aggravate thirst, dry constipation, or depletion if used too aggressively in already dry patients
  • Use with caution during pregnancy because its strong Qi-moving and descending action may disturb fetal stability in susceptible patients

Drug Interactions

  • Diabetes medications — Magnolia bark extract may enhance glucose-lowering effects and increase the risk of hypoglycemia (Moderate) Source: Memorial Sloan Kettering Integrative Medicine - Magnolia officinalis
  • Sleep or anxiety medications — Magnolia bark extract may increase sedative or anxiolytic effects (Moderate) Source: Memorial Sloan Kettering Integrative Medicine - Magnolia officinalis
  • Blood thinners — Magnolia bark extract may increase bleeding risk (Moderate) Source: Memorial Sloan Kettering Integrative Medicine - Magnolia officinalis
  • CYP450 substrate drugs — Magnolia bark extract may alter drug metabolism and change the effects of medications handled by CYP pathways (Moderate) Source: Memorial Sloan Kettering Integrative Medicine - Magnolia officinalis
  • P-gp substrate drugs — Magnolia bark extract may alter transporter-mediated drug disposition and modify medication exposure (Moderate) Source: Memorial Sloan Kettering Integrative Medicine - Magnolia officinalis
  • UGT substrate drugs — Magnolia bark extract may alter glucuronidation-dependent drug clearance (Moderate) Source: Memorial Sloan Kettering Integrative Medicine - Magnolia officinalis

Conditions