Use with caution. Review interactions and contraindications below.
TCM Properties
- Taste
- acrid, sweet
- Temperature
- hot
- Channels
- Heart, Kidney, Liver, Spleen
Traditional Use
Primary Actions
- Reinforces fire and supports Kidney and Spleen Yang - a major herb for cold limbs, sore low back, impotence, frequent urination, dawn diarrhea, and deep exhaustion when Ming Men fire is weak.
- Disperses cold and alleviates pain - used for cold congealing in the abdomen, chest, epigastrium, or channels, especially when pain is fixed, better with warmth, and worsened by cold exposure.
- Warms and unblocks the channels while moving Blood - classically selected for amenorrhea, dysmenorrhea, postpartum abdominal pain, cold Bi syndrome, and deep-rooted yin-type sores where cold and stasis knot together.
- Guides floating deficient fire back to its source and helps the Kidneys grasp Qi - applied when false upper heat coexists with cold below or when Kidney Yang fails to anchor breathing.
Secondary Actions
- Rou Gui is stronger, deeper, and more interior-warming than Gui Zhi because it comes from mature bark rather than younger twigs, so the two are related but not interchangeable.
- The bark is often added late in decoction or taken as powder so that its aromatic warming oils are not driven off by prolonged boiling.
Classic Formulas
- You Gui Wan (右归丸) - classic Kidney-Yang restoring formula in which Rou Gui helps rekindle Ming Men fire, warm the lower burner, and strengthen reproductive and lumbar weakness.
- Jin Gui Shen Qi Wan / Shen Qi Wan (金匮肾气丸) - foundational formula for Kidney-Yang deficiency with frequent urination, low back coldness, edema, and lower-body weakness, using Rou Gui to warm the source fire.
- Yang He Tang (阳和汤) - external-surgery classic for deep cold-type abscesses and yin-type sores, where Rou Gui helps warm the channels, dispel cold, and move constrained Blood and phlegm.
- Shao Fu Zhu Yu Tang (少腹逐瘀汤) - blood-stasis formula for cold-induced lower-abdominal pain and dysmenorrhea in which Rou Gui warms the channels so stasis can be dispersed.
Classical References
- Sacred Lotus records Rou Gui as spicy, sweet, and hot, entering the Heart, Kidney, Liver, and Spleen channels, and specifically cautions against use in Yin-deficiency fire, excess internal Heat, and pregnancy.
- Traditional Rou Gui monographs summarized in TCM reference sources describe the bark as reinforcing fire, strengthening Yang, dispersing cold, and warming the channels for cold-stasis pain and deficiency-cold reproductive disorders.
- TCM sources consistently distinguish Rou Gui from Gui Zhi by medicinal part and depth of action: bark is used for stronger interior warming, whereas twig is lighter and more surface-releasing.
Modern Research
Active Compounds
- Cinnamaldehyde (phenylpropanoid aldehyde) - the dominant aromatic constituent and a major anti-inflammatory and metabolic research marker
- 2-hydroxycinnamaldehyde and related cinnamaldehyde derivatives - compounds associated with nitric-oxide and NF-kappaB modulation
- Coumarin (benzopyrone) - a natural constituent relevant to hepatotoxicity concerns in some cinnamon products
- Cinnamic acid and cinnamyl alcohol - classic bark metabolites contributing to aroma and pharmacologic interest
- Procyanidins and other polyphenols - antioxidant and insulin-sensitizing fractions discussed in metabolic studies
Studied Effects
- A broad review of Cinnamomum cassia summarizes anti-inflammatory, analgesic, antidiabetic, anti-obesity, antimicrobial, antiviral, cardiovascular-protective, neuroprotective, and immunoregulatory activity across modern experimental research (PMID 31557828).
- Network-pharmacology and experimental work suggests Cinnamomum cassia may improve thermogenesis and cold resistance, which is a modern mechanistic parallel to Rou Gui's classical warming-Yang reputation (PMID 33388379).
- A randomized double-blind placebo-controlled trial in type 2 diabetes reported improved arterial stiffness and endothelial dysfunction parameters with Cinnamomum cassia, adding human cardiovascular-metabolic data to the evidence base (PMID 37262194).
- Compounds isolated from Cinnamomum cassia showed anti-diabetic-nephropathy activity in experimental work, aligning with the herb's traditional use for lower-burner Yang weakness and fluid dysregulation (PMID 25725434).
PubMed References
Safety & Interactions
Contraindications
- Pregnancy
- Yin deficiency with Fire signs
- Excess internal Heat
- Bleeding tendency or blood-heat hemorrhage
Cautions
- Some cinnamon products contain enough coumarin to raise hepatotoxicity concerns, especially with prolonged or heavy intake
- Medicinal Rou Gui doses are stronger than ordinary culinary cinnamon use and can aggravate heat signs, dry mouth, restlessness, or bleeding when misapplied
- Gastrointestinal upset and allergic reactions have been reported with cinnamon products
Drug Interactions
-
CYP450 substrate drugs
— Preclinical studies suggest cinnamon inhibits CYP2A6, CYP2C9, CYP2D, and CYP3A4 and may increase the risk of side effects from drugs metabolized by these enzymes (Moderate)
Source: Memorial Sloan Kettering Integrative Medicine - Cinnamon
-
Statins
— Concurrent use has been associated with hepatitis in a case report (Moderate)
Source: Memorial Sloan Kettering Integrative Medicine - Cinnamon
-
Pioglitazone
— Animal studies suggest cinnamon can increase pioglitazone bioavailability (Moderate)
Source: Memorial Sloan Kettering Integrative Medicine - Cinnamon