Cassia Bark

Chinese
肉桂
Pinyin
Rou Gui
Latin
Cortex Cinnamomi

TCM Properties

Taste
acrid, sweet
Temperature
hot
Channels
Heart, Kidney, Liver, Spleen

Traditional Use

Primary Actions

  • Reinforces fire and supports Kidney and Spleen Yang - a major herb for cold limbs, sore low back, impotence, frequent urination, dawn diarrhea, and deep exhaustion when Ming Men fire is weak.
  • Disperses cold and alleviates pain - used for cold congealing in the abdomen, chest, epigastrium, or channels, especially when pain is fixed, better with warmth, and worsened by cold exposure.
  • Warms and unblocks the channels while moving Blood - classically selected for amenorrhea, dysmenorrhea, postpartum abdominal pain, cold Bi syndrome, and deep-rooted yin-type sores where cold and stasis knot together.
  • Guides floating deficient fire back to its source and helps the Kidneys grasp Qi - applied when false upper heat coexists with cold below or when Kidney Yang fails to anchor breathing.

Secondary Actions

  • Rou Gui is stronger, deeper, and more interior-warming than Gui Zhi because it comes from mature bark rather than younger twigs, so the two are related but not interchangeable.
  • The bark is often added late in decoction or taken as powder so that its aromatic warming oils are not driven off by prolonged boiling.

Classic Formulas

  • You Gui Wan (右归丸) - classic Kidney-Yang restoring formula in which Rou Gui helps rekindle Ming Men fire, warm the lower burner, and strengthen reproductive and lumbar weakness.
  • Jin Gui Shen Qi Wan / Shen Qi Wan (金匮肾气丸) - foundational formula for Kidney-Yang deficiency with frequent urination, low back coldness, edema, and lower-body weakness, using Rou Gui to warm the source fire.
  • Yang He Tang (阳和汤) - external-surgery classic for deep cold-type abscesses and yin-type sores, where Rou Gui helps warm the channels, dispel cold, and move constrained Blood and phlegm.
  • Shao Fu Zhu Yu Tang (少腹逐瘀汤) - blood-stasis formula for cold-induced lower-abdominal pain and dysmenorrhea in which Rou Gui warms the channels so stasis can be dispersed.

Classical References

  • Sacred Lotus records Rou Gui as spicy, sweet, and hot, entering the Heart, Kidney, Liver, and Spleen channels, and specifically cautions against use in Yin-deficiency fire, excess internal Heat, and pregnancy.
  • Traditional Rou Gui monographs summarized in TCM reference sources describe the bark as reinforcing fire, strengthening Yang, dispersing cold, and warming the channels for cold-stasis pain and deficiency-cold reproductive disorders.
  • TCM sources consistently distinguish Rou Gui from Gui Zhi by medicinal part and depth of action: bark is used for stronger interior warming, whereas twig is lighter and more surface-releasing.

Modern Research

Active Compounds

  • Cinnamaldehyde (phenylpropanoid aldehyde) - the dominant aromatic constituent and a major anti-inflammatory and metabolic research marker
  • 2-hydroxycinnamaldehyde and related cinnamaldehyde derivatives - compounds associated with nitric-oxide and NF-kappaB modulation
  • Coumarin (benzopyrone) - a natural constituent relevant to hepatotoxicity concerns in some cinnamon products
  • Cinnamic acid and cinnamyl alcohol - classic bark metabolites contributing to aroma and pharmacologic interest
  • Procyanidins and other polyphenols - antioxidant and insulin-sensitizing fractions discussed in metabolic studies

Studied Effects

  • A broad review of Cinnamomum cassia summarizes anti-inflammatory, analgesic, antidiabetic, anti-obesity, antimicrobial, antiviral, cardiovascular-protective, neuroprotective, and immunoregulatory activity across modern experimental research (PMID 31557828).
  • Network-pharmacology and experimental work suggests Cinnamomum cassia may improve thermogenesis and cold resistance, which is a modern mechanistic parallel to Rou Gui's classical warming-Yang reputation (PMID 33388379).
  • A randomized double-blind placebo-controlled trial in type 2 diabetes reported improved arterial stiffness and endothelial dysfunction parameters with Cinnamomum cassia, adding human cardiovascular-metabolic data to the evidence base (PMID 37262194).
  • Compounds isolated from Cinnamomum cassia showed anti-diabetic-nephropathy activity in experimental work, aligning with the herb's traditional use for lower-burner Yang weakness and fluid dysregulation (PMID 25725434).

PubMed References

Safety & Interactions

Contraindications

  • Pregnancy
  • Yin deficiency with Fire signs
  • Excess internal Heat
  • Bleeding tendency or blood-heat hemorrhage

Cautions

  • Some cinnamon products contain enough coumarin to raise hepatotoxicity concerns, especially with prolonged or heavy intake
  • Medicinal Rou Gui doses are stronger than ordinary culinary cinnamon use and can aggravate heat signs, dry mouth, restlessness, or bleeding when misapplied
  • Gastrointestinal upset and allergic reactions have been reported with cinnamon products

Drug Interactions

  • CYP450 substrate drugs — Preclinical studies suggest cinnamon inhibits CYP2A6, CYP2C9, CYP2D, and CYP3A4 and may increase the risk of side effects from drugs metabolized by these enzymes (Moderate) Source: Memorial Sloan Kettering Integrative Medicine - Cinnamon
  • Statins — Concurrent use has been associated with hepatitis in a case report (Moderate) Source: Memorial Sloan Kettering Integrative Medicine - Cinnamon
  • Pioglitazone — Animal studies suggest cinnamon can increase pioglitazone bioavailability (Moderate) Source: Memorial Sloan Kettering Integrative Medicine - Cinnamon

Conditions