Cassia Bark
- Chinese
- 肉桂
- Pinyin
- Rou Gui
- Latin
- Cortex Cinnamomi
Known in TCM as Rou Gui (肉桂), this acrid and sweet, hot herb enters the Heart, Kidney, Liver, and Spleen. Traditionally, it reinforces fire and supports Kidney and Spleen Yang - a major herb for cold limbs, sore low back, impotence, frequent urination, dawn diarrhea, and deep exhaustion when Ming Men fire is weak, most often applied for kidney yang deficiency, low back pain, and dysmenorrhea. Modern research has identified Cinnamaldehyde among its active constituents.
Part used: Bark
Also Known As
Latin: Cortex Cinnamomi | Pinyin: Rou Gui | Chinese: 肉桂
TCM Properties
- Taste
- acrid, sweet
- Temperature
- hot
- Channels
- Heart, Kidney, Liver, Spleen
Traditional Use
Primary Actions
- Reinforces fire and supports Kidney and Spleen Yang - a major herb for cold limbs, sore low back, impotence, frequent urination, dawn diarrhea, and deep exhaustion when Ming Men fire is weak.
- Disperses cold and alleviates pain - used for cold congealing in the abdomen, chest, epigastrium, or channels, especially when pain is fixed, better with warmth, and worsened by cold exposure.
- Warms and unblocks the channels while moving Blood - classically selected for amenorrhea, dysmenorrhea, postpartum abdominal pain, cold Bi syndrome, and deep-rooted yin-type sores where cold and stasis knot together.
- Guides floating deficient fire back to its source and helps the Kidneys grasp Qi - applied when false upper heat coexists with cold below or when Kidney Yang fails to anchor breathing.
Secondary Actions
- Rou Gui is stronger, deeper, and more interior-warming than Gui Zhi because it comes from mature bark rather than younger twigs, so the two are related but not interchangeable.
- The bark is often added late in decoction or taken as powder so that its aromatic warming oils are not driven off by prolonged boiling.
Classic Formulas
- You Gui Wan (右归丸) - classic Kidney-Yang restoring formula in which Rou Gui helps rekindle Ming Men fire, warm the lower burner, and strengthen reproductive and lumbar weakness.
- Jin Gui Shen Qi Wan / Shen Qi Wan (金匮肾气丸) - foundational formula for Kidney-Yang deficiency with frequent urination, low back coldness, edema, and lower-body weakness, using Rou Gui to warm the source fire.
- Yang He Tang (阳和汤) - external-surgery classic for deep cold-type abscesses and yin-type sores, where Rou Gui helps warm the channels, dispel cold, and move constrained Blood and phlegm.
- Shao Fu Zhu Yu Tang (少腹逐瘀汤) - blood-stasis formula for cold-induced lower-abdominal pain and dysmenorrhea in which Rou Gui warms the channels so stasis can be dispersed.
Classical References
- Sacred Lotus records Rou Gui as spicy, sweet, and hot, entering the Heart, Kidney, Liver, and Spleen channels, and specifically cautions against use in Yin-deficiency fire, excess internal Heat, and pregnancy.
- Traditional Rou Gui monographs summarized in TCM reference sources describe the bark as reinforcing fire, strengthening Yang, dispersing cold, and warming the channels for cold-stasis pain and deficiency-cold reproductive disorders.
- TCM sources consistently distinguish Rou Gui from Gui Zhi by medicinal part and depth of action: bark is used for stronger interior warming, whereas twig is lighter and more surface-releasing.
Modern Research
Active Compounds
- Cinnamaldehyde (phenylpropanoid aldehyde) - the dominant aromatic constituent and a major anti-inflammatory and metabolic research marker
- 2-hydroxycinnamaldehyde and related cinnamaldehyde derivatives - compounds associated with nitric-oxide and NF-kappaB modulation
- Coumarin (benzopyrone) - a natural constituent relevant to hepatotoxicity concerns in some cinnamon products
- Cinnamic acid and cinnamyl alcohol - classic bark metabolites contributing to aroma and pharmacologic interest
- Procyanidins and other polyphenols - antioxidant and insulin-sensitizing fractions discussed in metabolic studies
Studied Effects
- A broad review of Cinnamomum cassia summarizes anti-inflammatory, analgesic, antidiabetic, anti-obesity, antimicrobial, antiviral, cardiovascular-protective, neuroprotective, and immunoregulatory activity across modern experimental research (PMID 31557828).
- Network-pharmacology and experimental work suggests Cinnamomum cassia may improve thermogenesis and cold resistance, which is a modern mechanistic parallel to Rou Gui's classical warming-Yang reputation (PMID 33388379).
- A randomized double-blind placebo-controlled trial in type 2 diabetes reported improved arterial stiffness and endothelial dysfunction parameters with Cinnamomum cassia, adding human cardiovascular-metabolic data to the evidence base (PMID 37262194).
- Compounds isolated from Cinnamomum cassia showed anti-diabetic-nephropathy activity in experimental work, aligning with the herb's traditional use for lower-burner Yang weakness and fluid dysregulation (PMID 25725434).
PubMed References
- Cinnamomum cassia Presl: A Review of Its Traditional Uses, Phytochemistry, Pharmacology and Toxicology (2019)
- Network pharmacology-based research uncovers cold resistance and thermogenesis mechanism of Cinnamomum cassia (2021)
- Cinnamomum cassia on Arterial Stiffness and Endothelial Dysfunction in Type 2 Diabetes Mellitus: Outcomes of a Randomized, Double-Blind, Placebo-Controlled Clinical Trial (2023)
- Anti-diabetic nephropathy compounds from Cinnamomum cassia (2015)
Safety & Interactions
Contraindications
- Pregnancy
- Yin deficiency with Fire signs
- Excess internal Heat
- Bleeding tendency or blood-heat hemorrhage
Cautions
- Some cinnamon products contain enough coumarin to raise hepatotoxicity concerns, especially with prolonged or heavy intake
- Medicinal Rou Gui doses are stronger than ordinary culinary cinnamon use and can aggravate heat signs, dry mouth, restlessness, or bleeding when misapplied
- Gastrointestinal upset and allergic reactions have been reported with cinnamon products
Drug Interactions
- CYP450 substrate drugs … Preclinical studies suggest cinnamon inhibits CYP2A6, CYP2C9, CYP2D, and CYP3A4 and may increase the risk of side effects from drugs metabolized by these enzymes (Moderate) Source: Memorial Sloan Kettering Integrative Medicine - Cinnamon
- Statins … Concurrent use has been associated with hepatitis in a case report (Moderate) Source: Memorial Sloan Kettering Integrative Medicine - Cinnamon
- Pioglitazone … Animal studies suggest cinnamon can increase pioglitazone bioavailability (Moderate) Source: Memorial Sloan Kettering Integrative Medicine - Cinnamon
Conditions
- Kidney Yang Deficiency Traditional ★★★★★ JSON
- Low Back Pain Traditional ★★★★☆ JSON
- Dysmenorrhea Traditional ★★★★☆ JSON
- Frequent Urination Traditional ★★★☆☆ JSON
- Impotence Traditional ★★★★☆ JSON
Frequently Asked Questions
What is Cassia Bark used for?
Cassia Bark is traditionally used to Reinforces fire and supports Kidney and Spleen Yang - a major herb for cold limbs, sore low back, impotence, frequent urination, dawn diarrhea, and deep exhaustion when Ming Men fire is weak., Disperses cold and alleviates pain - used for cold congealing in the abdomen, chest, epigastrium, or channels, especially when pain is fixed, better with warmth, and worsened by cold exposure., Warms and unblocks the channels while moving Blood - classically selected for amenorrhea, dysmenorrhea, postpartum abdominal pain, cold Bi syndrome, and deep-rooted yin-type sores where cold and stasis knot together., Guides floating deficient fire back to its source and helps the Kidneys grasp Qi - applied when false upper heat coexists with cold below or when Kidney Yang fails to anchor breathing.. Research has investigated its effects on: A broad review of Cinnamomum cassia summarizes anti-inflammatory, analgesic, antidiabetic, anti-obesity, antimicrobial, antiviral, cardiovascular-protective, neuroprotective, and immunoregulatory activity across modern experimental research (PMID 31557828).; Network-pharmacology and experimental work suggests Cinnamomum cassia may improve thermogenesis and cold resistance, which is a modern mechanistic parallel to Rou Gui's classical warming-Yang reputation (PMID 33388379)..
What are other names for Cassia Bark?
Cassia Bark is also known as Cinnamomi. In TCM: 肉桂 (Rou Gui); Cortex Cinnamomi.
Is Cassia Bark safe during pregnancy?
Cassia Bark is not recommended during pregnancy.
What are the contraindications for Cassia Bark?
Cassia Bark should not be used in: Pregnancy; Yin deficiency with Fire signs; Excess internal Heat; Bleeding tendency or blood-heat hemorrhage. Consult a qualified practitioner before use.
Does Cassia Bark interact with any medications?
Cassia Bark may interact with: CYP450 substrate drugs - Preclinical studies suggest cinnamon inhibits CYP2A6, CYP2C9, CYP2D, and CYP3A4 and may increase the risk of side effects from drugs metabolized by these enzymes - (Moderate severity); Statins - Concurrent use has been associated with hepatitis in a case report - (Moderate severity); Pioglitazone - Animal studies suggest cinnamon can increase pioglitazone bioavailability - (Moderate severity). Always inform your healthcare provider of any herbal supplements you are taking.