Chlorpheniramine Maleate — Safety & Interactions
Pu Er Min · Chlorpheniramini Maleas
Use with caution. Practitioner review recommended before use.
Contraindications
- Known hypersensitivity to chlorpheniramine or related antihistamines
- Narrow-angle glaucoma
- Urinary retention or severe prostatic obstruction
- Concurrent monoamine oxidase inhibitor use
Cautions
- Sedation, slowed reaction time, and impaired concentration are common enough that driving and alcohol co-use deserve explicit caution
- As a first-generation antihistamine, chlorpheniramine can produce anticholinergic adverse effects such as dry mouth, constipation, blurred vision, and urinary retention
- Older adults and young children are more vulnerable to paradoxical CNS effects, confusion, or excessive sedation
- Rare severe hypersensitivity reactions, including anaphylaxis, have been reported despite the drug's common routine use
Drug Interactions
| Drug Class / Substrate | Mechanism | Severity | Source |
|---|---|---|---|
| Alcohol and other CNS depressants | Additive sedation and psychomotor impairment may occur | Major | Chlorpheniramine pharmacology and prescribing literature |
| Monoamine oxidase inhibitors | MAO inhibitors can prolong and intensify anticholinergic and CNS effects | Major | Chlorpheniramine pharmacology and prescribing literature |
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before using herbal medicines, especially if you take prescription medications.