Chrysanthemum Flower — Safety & Interactions
Ju Hua · Flos Chrysanthemi
Use with caution. Practitioner review recommended before use.
Contraindications
- Ragweed or Asteraceae family allergy
- Patients with clear cold deficiency patterns aggravated by cool herbs
Cautions
- Chrysanthemum can trigger cross-reactive allergy in people sensitive to ragweed and related Asteraceae plants
- Large amounts of cool chrysanthemum tea may aggravate chronic loose stools, poor appetite, or cold middle-burner patterns
- Concentrated extracts may interact more strongly than ordinary tea-level intake
- A documented transplant case and in-vitro work support caution around CYP3A4 and P-glycoprotein substrate drugs
Drug Interactions
| Drug Class / Substrate | Mechanism | Severity | Source |
|---|---|---|---|
| CYP3A4 substrate drugs | Chrysanthemum extracts may alter CYP3A4 activity and change blood levels of susceptible drugs | Moderate | Memorial Sloan Kettering Integrative Medicine - Chrysanthemum |
| P-glycoprotein substrate drugs | Chrysanthemum may inhibit P-gp transport and increase exposure to susceptible medications | Moderate | Memorial Sloan Kettering Integrative Medicine - Chrysanthemum |
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before using herbal medicines, especially if you take prescription medications.