Cuttlebone

Chinese
海螵蛸
Pinyin
Hai Piao Xiao
Latin
Os Sepiellae Seu Sepiae

Known in TCM as Hai Piao Xiao (海螵蛸), this salty and astringent, slightly warm herb enters the Kidney and Liver. Traditionally, it secures essence and stops leukorrhea - Hai Piao Xiao is classically used for spermatorrhea, excessive vaginal discharge, and chronic leakage patterns involving instability of the lower burner, most often applied for acid reflux, gastric ulcer, and uterine bleeding. Modern research has identified Calcium among its active constituents.

Part used: Bone Also known as: Sepiella

TCM Properties

Taste
salty, astringent
Temperature
slightly warm
Channels
Kidney, Liver

Traditional Use

Primary Actions

  • Secures essence and stops leukorrhea - Hai Piao Xiao is classically used for spermatorrhea, excessive vaginal discharge, and chronic leakage patterns involving instability of the lower burner.
  • Astringes bleeding - the powdered shell is used for uterine bleeding and other chronic bleeding patterns where an astringent mineral substance is appropriate.
  • Restrains acidity and alleviates pain - it is a classic herb for acid regurgitation, epigastric discomfort, and ulcer-type stomach pain, especially when calcined or finely powdered.
  • Dries dampness and promotes healing externally - topical use extends to weeping sores, ulcerations, and traumatic bleeding where the powder can dry discharge and protect tissue.

Secondary Actions

  • Hai Piao Xiao is both a lower-burner astringent and an upper-digestive mineral antacid, which is why it appears in very different kinds of formulas.
  • In modern practice it is commonly powdered and taken for stomach-acid complaints or applied externally rather than relied on as a long-boiled crude shell.

Classic Formulas

  • Hai Piao Xiao with Qian Shi and Shan Zhu Yu - a classic lower-burner astringent strategy for spermatorrhea and chronic leukorrhea.
  • Hai Piao Xiao with Wa Leng Zi - a traditional mineral pairing for acid regurgitation and epigastric pain when both astringing and antacid action are needed.
  • Hai Piao Xiao with Bai Ji for powder use - a familiar hemostatic and tissue-protective combination for bleeding ulcers or external sores.

Classical References

  • Traditional references describe Hai Piao Xiao as salty, astringent, and slightly warm, entering the Liver and Kidney to secure essence, stop bleeding, and restrain acidity.
  • The herb is also commonly known as Wu Zei Gu, and the two names often refer to the same medicinal cuttlebone material in classical and modern usage.
  • Its dual use for chronic leakage below and sour regurgitation above is one of the defining features that distinguishes it from many other marine shell medicinals.

Modern Research

Active Compounds

  • Calcium carbonate and aragonite - the major mineral matrix responsible for antacid and scaffold-like properties
  • Chitin and chitosan-related shell components - relevant to hemostatic and biomaterial research
  • Trace minerals and amino-acid residues - minor constituents used in quality-control studies of Os Sepiae

Studied Effects

  • In a rat model of NSAID-related gastric injury, cuttlebone promoted healing of acute gastric mucosal lesions, which supports the traditional use of Hai Piao Xiao for acid injury and ulcer-type stomach pain (PMID 33082835).
  • A marine biomaterials study showed that cuttlebone can serve as a useful calcium-rich scaffold for bone graft preparation, reinforcing the structural and tissue-supportive properties of this shell medicine (PMID 29616431).
  • A recent hydrogel study used nanoscale cuttlebone to improve hemostatic and antibacterial wound-dressing performance, offering a modern analogue for the herb's classical external bleeding and wound uses (PMID 40245568).

PubMed References

Safety & Interactions

Contraindications

  • Constipation from fluid depletion without leakage or acidity patterns
  • Heat-type irritability without a clear astringent indication

Cautions

  • As a calcium-rich shell medicine, Hai Piao Xiao can reduce absorption of certain medications if taken at the same time.
  • Only properly cleaned medicinal cuttlebone should be used because crude marine material may carry contamination or quality-control problems.
  • The powdered shell is best matched to leakage, bleeding, and acidity patterns rather than taken casually as a long-term supplement.

Drug Interactions

  • Fluoroquinolone antibiotics - calcium-rich shell minerals can chelate the drug and reduce absorption; separate by several hours
  • Tetracycline antibiotics - concurrent mineral intake can lower antibiotic bioavailability; stagger dosing
  • Levothyroxine - calcium-containing minerals may impair thyroid hormone absorption; separate by at least 4 hours
  • Iron supplements - calcium can decrease iron absorption when taken together

Conditions