Cuttlefish Bone, Cuttlebone — Safety & Interactions
Wu Zei Gu · Ossa Sepiae
Use with caution. Practitioner review recommended before use.
Contraindications
- Constipation from dryness without leakage or acidity patterns
- Heat agitation without a clear astringent indication
Cautions
- As a calcium-rich shell medicine, Wu Zei Gu can reduce absorption of certain medications if taken together.
- Only properly cleaned medicinal shell should be used because crude marine material may contain contaminants or variable mineral quality.
- This is an astringent mineral drug, not a routine calcium supplement.
Drug Interactions
| Drug Class / Substrate | Mechanism | Severity | Source |
|---|---|---|---|
| Fluoroquinolone antibiotics - calcium-rich shell minerals can chelate the drug and reduce absorption; separate by several hours | |||
| Tetracycline antibiotics - concurrent mineral intake can lower antibiotic bioavailability; stagger dosing | |||
| Levothyroxine - calcium-containing minerals may impair thyroid hormone absorption; separate by at least 4 hours | |||
| Iron supplements - calcium can decrease iron absorption when taken together | |||
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before using herbal medicines, especially if you take prescription medications.