Dogbane Leaf

Chinese
罗布麻叶
Pinyin
Luo Bu Ma Ye
Latin
Folium Apocyni Veneti

TCM Properties

Taste
sweet, bitter
Temperature
cool
Channels
Liver

Traditional Use

Primary Actions

  • Clears heat and helps lower rising pressure - Luo Bu Ma leaf is used in modern TCM practice for hypertension-like presentations with dizziness, headache, irritability, and Liver heat or rising Yang patterns.
  • Strengthens the Heart and promotes urination - traditional indications extend to palpitations, edema, and fluid retention when heat and circulatory strain coexist.
  • Calms agitation and eases restlessness - the leaf is widely used as a medicinal tea when irritability, poor sleep, and tension accompany elevated pressure.

Secondary Actions

  • Luo Bu Ma sits at the border of herb and tea, and many people encounter it more often in medicated-tea or wellness-drink form than in classical decoction formulas.
  • The leaf material is the part most commonly used; later shorthand often says Luo Bu Ma even when the actual medicinal item is Luo Bu Ma Ye.

Classic Formulas

  • Luo Bu Ma tea preparations - later medicinal-tea traditions use the leaf alone or with Ju Hua for dizziness, irritability, and elevated pressure.
  • Luo Bu Ma with Ze Xie or Che Qian Zi - later pairing logic when head pressure coexists with edema and scanty urination.

Classical References

  • TCM Wiki describes Luo Bu Ma as sweet, bitter, and cool, entering the Liver channel, with actions of clearing heat, decreasing blood pressure, strengthening the heart, and inducing diuresis.
  • Modern Chinese herb manuals commonly present Luo Bu Ma as a mild but useful leaf for hypertension, edema, and agitation, especially in tea form.

Modern Research

Active Compounds

  • Flavonoids such as hyperoside, isoquercitrin, and quercetin derivatives - major bioactive constituents repeatedly linked to vascular and antioxidant activity
  • Chlorogenic acid and related phenolic acids - polyphenols contributing to anti-inflammatory and metabolic research interest
  • Polysaccharides - investigated for gut, metabolic, and immunomodulatory effects
  • Dietary fiber fractions - part of the leaf's modern functional-food profile

Studied Effects

  • A 2024 review cataloged hundreds of compounds from Apocynum venetum leaves and summarized broad antioxidant, anti-inflammatory, cardioprotective, and metabolic research around the plant (PMID 39447713).
  • In a 2023 experimental study, Apocynum venetum leaf extract improved doxorubicin-induced cardiotoxicity in mice, supporting ongoing cardiovascular interest in the herb beyond its traditional tea reputation (PMID 38074154).
  • Polysaccharide-rich Apocynum venetum leaf extracts improved glucose and lipid metabolism and modulated gut microbiota in diabetic mice, illustrating the modern functional-food direction of Luo Bu Ma research (PMID 32361160).

PubMed References

Safety & Interactions

Contraindications

  • Low blood pressure or marked deficiency with dizziness from non-heat causes
  • Spleen deficiency with loose stools if cooling teas aggravate digestion

Cautions

  • Although often sold as a tea, Luo Bu Ma can still have physiologic effects and is not equivalent to an inert beverage.
  • Its cooling and pressure-lowering profile may be too dispersing for depleted or hypotensive users.
  • Modern research is promising but remains far stronger in preclinical and functional-food settings than in large clinical trials.

Drug Interactions

  • Antihypertensive drugs or diuretics - Luo Bu Ma may add to blood-pressure-lowering or fluid-lowering effects.
  • Sedatives - calming tea or extract use may increase drowsiness in sensitive users.

Conditions