Donkey Hide Gelatin

Chinese
阿胶
Pinyin
E Jiao
Latin
Colla Corii Asini

TCM Properties

Taste
sweet
Temperature
neutral
Channels
Lung, Liver, Kidney, Heart

Traditional Use

Primary Actions

  • Tonifies blood and enriches deficiency - E Jiao is a major blood tonic used for pallor, dizziness, palpitations, and chronic weakness when blood depletion is central.
  • Stops bleeding while also nourishing - it is classically used for uterine bleeding, spotting, hemoptysis, and other bleeding patterns where deficiency and dryness are involved rather than blazing excess heat alone.
  • Nourishes Yin and moistens the Lung - traditional use extends to dry cough, dry throat, irritative cough, and blood-streaked sputum from dryness or deficiency heat.
  • Calms irritability from deficiency - by enriching blood and Yin, E Jiao is also used when restlessness or insomnia reflects depletion rather than excess obstruction.

Secondary Actions

  • Because E Jiao is rich and cloying, it is often dissolved into strained decoctions near the end rather than boiled hard with the rest of the herbs.
  • High-quality sourcing and authentication matter greatly because commercial E Jiao quality varies and counterfeit or adulterated products are a long-standing concern.

Classic Formulas

  • Jiao Ai Tang - classic formula for uterine bleeding and threatened fetal instability in which E Jiao nourishes blood while helping stop bleeding.
  • Huang Lian E Jiao Tang - from Shang Han Lun, using E Jiao to nourish Yin and blood while clearing Heart-Kidney irritability with insomnia and restlessness.
  • Qing Zao Jiu Fei Tang - includes E Jiao to moisten the Lung and relieve dry cough from autumn dryness or chronic fluid damage.

Classical References

  • Traditional materia medica consistently class E Jiao as sweet and neutral, entering the Lung, Liver, and Kidney to tonify blood, stop bleeding, nourish Yin, and moisten dryness.
  • Its dual role of stopping bleeding without strongly drying and enriching blood without being sharply moving explains why E Jiao is so prominent in gynecologic and deficiency-dryness formulas.

Modern Research

Active Compounds

  • Collagen and gelatin proteins - the dominant structural basis of E Jiao
  • Collagen-derived peptides - low-molecular-weight fractions increasingly studied for bioactivity and quality control
  • Amino acids - nutritive and analytical constituents used in product characterization
  • Species-specific marker peptides - important for authentication of true donkey-hide gelatin products

Studied Effects

  • A randomized controlled trial reported that Ejiao improved blood-deficient symptom scores and reduced declines in blood indices among women with blood-deficient symptoms, supporting continued clinical interest in the classic blood-tonic category (PMID 34707496).
  • Collagen-derived peptides isolated from Colla Corii Asini showed hematopoietic activity in experimental work, offering a plausible biochemical bridge for its traditional blood-nourishing reputation (PMID 26911525).
  • Proteomic and marker-peptide research continues to focus heavily on authentication and quality control, reflecting the commercial importance and adulteration risk of E Jiao products (PMID 28670118).

PubMed References

Safety & Interactions

Contraindications

  • Spleen or Stomach weakness with poor appetite, bloating, or loose stools
  • Thick phlegm or damp obstruction without underlying deficiency

Cautions

  • E Jiao is rich and can be difficult to digest if used inappropriately or in large amounts.
  • Commercial authenticity and source transparency matter because adulteration is a well-known concern.
  • Even though E Jiao appears in pregnancy-related classical formulas, that does not make unsupervised pregnancy use broadly appropriate.

Conditions