Use with caution. Review interactions and contraindications below.
TCM Properties
- Taste
- salty
- Temperature
- cold
- Channels
- Bladder, Liver, Lung, Spleen
Traditional Use
Primary Actions
- Clears heat and extinguishes internal wind - Di Long is classically used for high fever, spasms, convulsions, and heat-driven agitation in which internal wind has been stirred by replete heat.
- Unblocks channels and collaterals - it is a core animal medicine for hemiplegia, numbness, facial paralysis, red swollen painful obstruction, and post-stroke patterns where movement has been blocked by stasis and heat.
- Clears Lung heat and calms wheezing - traditional use extends to asthma, labored breathing, and stubborn wheeze when heat and obstruction bind the Lung.
- Promotes urination and reduces swelling - it can be added when bladder heat, edema, or difficult urination are part of the pattern.
Secondary Actions
- Di Long is prized for strong channel-opening action and is usually chosen when a formula needs something more penetrating than ordinary plant herbs.
- Modern extract products such as lumbrokinase are not interchangeable with crude TCM earthworm and should not be treated as simple equivalents.
Classic Formulas
- Bu Yang Huan Wu Tang - classic post-stroke formula in which Di Long helps reopen the channels and collaterals.
- Di Long with Gou Teng, Jiang Can, and Quan Xie - a traditional internal-wind combination for spasms, tremors, and convulsions.
- Di Long with Ma Huang and Xing Ren - a classic wheezing strategy for Lung heat with difficult breathing.
Classical References
- Shen Nong Ben Cao Jing and later materia medica preserve Di Long's reputation for treating heat, spasms, and channel obstruction.
- Traditional herbology links its animal, drilling, penetrating character to its ability to reach the collaterals and unblock what is stuck.
- Modern pharmacopoeias distinguish several official source species but preserve the same broad functional profile of clearing heat, stopping spasms, and opening the channels.
Modern Research
Active Compounds
- Lumbrokinase and related fibrinolytic enzymes - the best-known protein fraction associated with antithrombotic research
- Other fibrinolytic proteins and proteases - additional earthworm enzymes studied for clot-dissolving activity
- Nucleosides such as hypoxanthine, inosine, and related small molecules - important markers in earthworm quality-control work
- Peptides and amino acid-rich protein fractions - broader bioactive material investigated in anti-inflammatory and antifibrotic models
Studied Effects
- Oral Pheretima aspergillum improved neurologic recovery in a rat middle-cerebral-artery occlusion model, supporting ongoing interest in stroke and collateral-opening applications (PMID 24082328).
- Chinese medicine Di-Long from Pheretima vulgaris showed anti-rheumatoid-arthritis effects in preclinical work through NF-kB and chemotaxis-related pathways, aligning with traditional painful-obstruction use (PMID 35033948).
- A 2024 meta-analysis concluded that lumbrokinase may have adjunctive potential in acute ischemic stroke, but product standardization and trial quality remain important limitations (PMID 40933244).
PubMed References
Safety & Interactions
Contraindications
- Cold deficiency patterns without heat, wind, or obstruction
- Known allergy to animal-derived medicines
- Active bleeding disorders without close supervision
Cautions
- Di Long extracts and lumbrokinase-type products may affect coagulation and should be treated more cautiously than the herb's traditional reputation alone might suggest.
- Commercial Pheretima products can face quality and contamination issues, including documented heavy-metal concerns in some market samples.
- MSK page not found - drug interaction data not available from Memorial Sloan Kettering integrative medicine database
Drug Interactions
- Anticoagulants or antiplatelet drugs - theoretical additive bleeding risk
- Fibrinolytic or thrombolytic medications - theoretical additive clot-dissolving effect