Psoralea Fruit
- Chinese
- 破故纸
- Pinyin
- Po Gu Zhi
- Latin
- Fructus Psoraleae Corylifoliae
Known in TCM as Po Gu Zhi (破故纸), this sweet and bitter and astringent, warm herb enters the Kidney, Spleen, and Lung. Traditionally, it warms Kidney yang and restores lower-burner fire - Po Gu Zhi is an older-name record for the same classic herb used in cold weakness, impotence, infertility, and sore low back, most often applied for kidney yang deficiency, frequent urination, and diarrhea. Modern research has identified Psoralen among its active constituents.
Part used: Fruit Also known as: Psoralea
TCM Properties
- Taste
- sweet, bitter, astringent
- Temperature
- warm
- Channels
- Kidney, Spleen, Lung
Traditional Use
Primary Actions
- Warms Kidney yang and restores lower-burner fire - Po Gu Zhi is an older-name record for the same classic herb used in cold weakness, impotence, infertility, and sore low back.
- Secures essence and shrinks urination - it is widely used for spermatorrhea, enuresis, urinary frequency, and other leakage patterns from deficient Kidneys.
- Warms the Spleen and checks chronic dawn diarrhea - it is especially useful when cold deficiency drives early-morning stool with abdominal chill and fatigue.
- Assists the Kidney in grasping qi - traditional combinations use it for chronic wheezing or dyspnea when deficiency prevents the lower burner from receiving breath.
Secondary Actions
- Po Gu Zhi is the older or alternate name commonly written with the character 破, while Bu Gu Zhi is the dominant modern naming form for the same medicinal fruit.
- Like the main Bu Gu Zhi record, this herb also appears in topical vitiligo practice because the source plant contains photosensitizing furocoumarins.
Classic Formulas
- Si Shen Wan - classic dawn-diarrhea formula using Po Gu Zhi or Bu Gu Zhi naming interchangeably in many lineages.
- Qing E Wan and related lumbar-tonic formulas rely on Po Gu Zhi for warming the Kidneys and strengthening the low back.
- Chronic wheezing formulas combine it with Ren Shen, Hu Tao Rou, or Chen Xiang when the Kidney cannot grasp qi.
Classical References
- TCMWiki lists Po Gu Zhi as an accepted naming form and records its warm, sweet-bitter-astringent action on the Kidney, Spleen, and Lung.
- Traditional herbology treats Po Gu Zhi and Bu Gu Zhi as the same classic psoralea fruit rather than as separate medicinals.
Modern Research
Active Compounds
- Psoralen and isopsoralen - hallmark furocoumarins that drive both therapeutic interest and safety concerns
- Bakuchiol - prominent meroterpene frequently discussed in Psoralea studies
- Bavachin and bavachalcone - bioactive flavonoid-type constituents
- Seed polysaccharides - modern fractions investigated for bone and immune effects
Studied Effects
- A 2018 review covered the ethnobotanical, biological, and chemical aspects of Psoralea corylifolia, giving a broad overview relevant to both Bu Gu Zhi and Po Gu Zhi naming traditions (PMID 29243333).
- A 2025 study reported anti-osteoclast and anti-osteoporosis effects of polysaccharides from Psoralea corylifolia seeds in preclinical work (PMID 40403806).
- A 2019 rat study highlighted hepatotoxicity after long-term exposure to psoralen and isopsoralen, reinforcing the main safety concern for concentrated Psoralea use (PMID 31684074).
PubMed References
- Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: A review. (2018)
- Polysaccharides from Psoralea corylifolia seeds suppress osteoclastogenesis and alleviate osteoporosis. (2025)
- Long-Term Exposure of Psoralen and Isopsoralen Induced Hepatotoxicity and Serum Metabolites Profiles Changes in Female Rats. (2019)
Safety & Interactions
Contraindications
- Yin deficiency with heat or deficiency fire
- Constipation from dryness or internal heat
- Active liver disease without qualified supervision
Cautions
- Psoralea fruit carries hepatotoxic risk, especially in concentrated extracts, prolonged courses, or unsupervised high dosing.
- Its psoralen compounds can increase photosensitivity, particularly in topical or strongly extracted preparations.
- MSK page not found - drug interaction data not available from Memorial Sloan Kettering integrative medicine database
Conditions
- Kidney Yang Deficiency Traditional ★★★★☆ JSON
- Frequent Urination Traditional ★★★★☆ JSON
- Diarrhea Traditional ★★★★☆ JSON
- Impotence Traditional ★★★★☆ JSON
- Wheezing Traditional ★★★☆☆ JSON