Pedunculate Herpetospermum Seed
- Chinese
- 波棱瓜子
- Pinyin
- Bo Leng Gua Zi
- Latin
- Fructus Herpetospermi Pedunculosi
Known in TCM as Bo Leng Gua Zi (波棱瓜子), this bitter, cold herb enters the Liver, Gallbladder, and Stomach. Traditionally, it clears heat and protects the Liver - Bo Leng Gua Zi is a well-known Tibetan medicine for heat-type liver disorders, especially jaundice and hepatitis-pattern illness, most often applied for hepatitis, jaundice, and cholecystitis. Modern research has identified Herpetin among its active constituents.
Part used: Fruit Also known as: Herpetospermi
TCM Properties
- Taste
- bitter
- Temperature
- cold
- Channels
- Liver, Gallbladder, Stomach
Traditional Use
Primary Actions
- Clears heat and protects the Liver - Bo Leng Gua Zi is a well-known Tibetan medicine for heat-type liver disorders, especially jaundice and hepatitis-pattern illness.
- Resolves damp-heat in the hepatobiliary system - traditional use extends to cholecystitis, liver heat, and yellowing disorders with bitter-damp features.
- Supports digestion and relieves food stagnation-type discomfort - it is also used when dyspepsia or indigestion accompanies liver-gallbladder heat.
- Detoxifies and assists recovery in complex liver disease formulas - it is usually prescribed as part of broader Tibetan or integrative hepatic formulas rather than as a simple single-herb home remedy.
Secondary Actions
- Bo Leng Gua Zi is much more rooted in Tibetan medicine than in mainstream Han-style everyday TCM prescribing, so its channel mapping is less standardized than classical Chinese formula herbs.
- Its strongest traditional identity is hepatobiliary rather than general digestive or tonic use.
Classic Formulas
- Tibetan liver-disease prescriptions use Bo Leng Gua Zi as a key seed for icterohepatitis, gallbladder heat, and chronic liver dysfunction.
- Integrative damp-heat liver formulas may pair it with Yin Chen, Jin Qian Cao, or other hepatobiliary herbs when jaundice and heat-toxin patterns dominate.
- Digestive-support formulas combine it with qi-moving and damp-resolving herbs when dyspepsia accompanies liver-gallbladder heat.
Classical References
- The 2024 comprehensive review on Herpetospermum pedunculosum traces Bo Leng Gua Zi back to early Tibetan medical literature and emphasizes its classic role in protecting the liver, clearing heat, and detoxifying.
- A Frontiers review on Tibetan medicines for liver diseases describes the seed as bitter and cold and especially associated with icterohepatitis, viral hepatitis, cholecystitis, and dyspepsia.
Modern Research
Active Compounds
- Herpetin - a lignan frequently discussed in Herpetospermum pharmacology
- Herpetone and related lignans - major phytochemicals linked to hepatoprotective interest
- Coumarins and terpenes - broader constituent groups reported in seed reviews
- Fatty acids and seed oils - supportive components in modern phytochemical profiling
Studied Effects
- A 2024 comprehensive review covered the traditional utilization, botany, phytochemistry, pharmacology, processing, and application of Herpetospermum pedunculosum seeds, with strong emphasis on hepatoprotective and anticholestatic effects (PMID 39749198).
- A 2019 physiological and metabolomic study examined adaptation strategies of Herpetospermum pedunculosum across altitude gradients, adding useful botanical and metabolomic context to this Tibetan medicinal plant (PMID 31159723).
- A 2006 phytochemical paper reported a new sesqui-norlignan from Herpetospermum pedunculosum, illustrating the seed's distinctive lignan chemistry (PMID 17007360).
PubMed References
- Traditional utilization, botany, phytochemistry, pharmacology, pharmaceutical analysis, processing and application of the seeds of Herpetospermum pedunculosum (Ser.) C.B. Clarke: a comprehensive review. (2024)
- The adaptation strategies of Herpetospermum pedunculosum (Ser.) Baill at altitude gradient of the Tibetan plateau by physiological and metabolomic methods. (2019)
- [A new sesqui-norlignan from Herpetospermum pedunculosum]. (2006)
Safety & Interactions
Contraindications
- Cold weak digestion with loose stools
- Patterns without heat, damp-heat, or hepatobiliary involvement
Cautions
- Outside Tibetan and specialist use, standardized dosing and product quality may be inconsistent.
- Most modern evidence remains preclinical and focused on extracts rather than ordinary clinical decoction practice.
- MSK page not found - drug interaction data not available from Memorial Sloan Kettering integrative medicine database
Conditions
- Hepatitis Traditional ★★★★☆ JSON
- Jaundice Traditional ★★★★☆ JSON
- Cholecystitis Traditional ★★★★☆ JSON
- Dyspepsia Traditional ★★★☆☆ JSON
- Indigestion Traditional ★★★☆☆ JSON